BIGG

The use of molecular line probe assays for the detection of resistance to second-line anti-tuberculosis drugs: policy guidance

World Health Organization.

This document provides a summary of the evidence and recommendations for the use of SL-LPA for the detection of mutations associated with resistance to fluoroquinolones and SLID in patients with RR-TB and/or MDR-TB. The objectives of this policy guidance are to assess and compare the diagnostic accuracy ...

Tuberculosis Resistente a Múltiples Medicamentos/diagnóstico, Antibióticos Antituberculosos/farmacología, Técnicas de Sonda Molecular, Pruebas de Sensibilidad Microbiana, Fluoroquinolonas/uso terapéutico, Farmacorresistencia Bacteriana/genética, Genotipo, Mutación, Tuberculosis Resistente a Múltiples Medicamentos/genética, Mycobacterium tuberculosis/efectos de los fármacos, Mycobacterium tuberculosis/genética

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The use of delamanid in the treatment of multidrug-resistant tuberculosis in children and adolescents: interim policy guidance

The specific objectives were to evaluate the harms to benefits ratio of delamanid in combination with the currently recommended MDR-TB treatment regimen in children. Based on this evaluation, to develop recommendations on the use of delamanid as part of WHO-recommended longer MDR-TB treatment regimens, a...